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Heam Polymerization and its Inhibition by Antimalarial Drug

Hemozoin is considered to be a suitable target to develop new antimalarial drug
by Sanjeev Kumar Shukla - Sold by Dodax EU
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Sanjeev Kumar Shukla Heam Polymerization and its Inhibition by Antimalarial Drug
Sanjeev Kumar Shukla - Heam Polymerization and its Inhibition by Antimalarial Drug

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Delivery: between 2021-02-03 and 2021-02-05
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Description

Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.

Contributors

Author Sanjeev Kumar Shukla

Author Ramesh Chandra

Author S. K. Puri

Product Details

DUIN 13BSQUT7CB4

GTIN 9783848433971

Language English

Pages 64

Product type Paperback

Dimension 8.66  inches

$63.99
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