Comprative Study on Effect of Natural & Synthetic Superdisintegrants - Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants

by Ray, Chanda
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Ray, Chanda Comprative Study on Effect of Natural & Synthetic Superdisintegrants - Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants
Ray, Chanda - Comprative Study on Effect of Natural & Synthetic Superdisintegrants - Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants

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Description

The study was undertaken with an aim to formulate Mouth Dissolving tablets of Diclofenac Sodium containing Fenugreek and SSG as natural and artificial superdisintegrant respectively and to compare its release profile with the same. Granules were evaluated for tests, bulk density, tapped density, compressibility index and hausner ratio before using punched as tablets. In vitro dissolution test are found for 6 batches. From these results AF6 was selected as optimized formulation. All the formulation shows the good blend properties for direct compression and hence tablets were prepared by using direct compression technology. This rapid disintegration of the FDTs was due to the penetration of saliva into the pores of the tablet, which lead to the swelling of superdisintegrant to create enough hydrodynamic pressure for quick and complete disintegration of the tablet. Fenugreek was effective. Hence it can be concluded that instead of using artificial superdisintegrant, we use should natural because they give better dissolution profile, are cheaper, abundantly available, non toxic and non-irritating in nature.

Contributors

Author:
Ray, Chanda

Further information

Biography Artist:
Chanda Ray, M.Pharm, Studied Pharmacy at Mahamaya Technical University, Assistant Professor at Lloyd Technical Campus, Greater Noida.
Language:
Englisch
Number of Pages:
136
Media Type:
Taschenbuch
Publisher:
LAP Lambert Academic Publishing

Master Data

Product Type:
Paperback book
Release date:
December 29, 2012
Package Dimensions:
0.229 x 0.152 x 0.008 m; 0.249 kg
GTIN:
09783659315725
DUIN:
CVFAAUSGTKQ
$76.99
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