Novel Techniques to Enhance Bioavailability of Poorly Soluble Drugs

by Nagabandi, Vijaykumar
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Nagabandi, Vijaykumar Novel Techniques to Enhance Bioavailability of Poorly Soluble Drugs
Nagabandi, Vijaykumar - Novel Techniques to Enhance Bioavailability of Poorly Soluble Drugs

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Description

Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately on the solubility of drug molecules. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation that produces pharmacological response. Currently only 8% of new drug candidates have both high solubility and permeability. Aqueous solubility of any therapeutically active substance is a key property; it governs dissolution, absorption and thus the In Vivo efficacy. For highly permeable and poorly soluble drug the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. The poor dissolution rate of waterinsoluble drugs is still a major problem confronting the pharmaceutical industry. There are several techniques to enhance the dissolution of poorly soluble drugs.The main objective of this work is to develop and explore new formulations for enhancing the bioavailability of highly permeable and poorly soluble nonsteroidal antiinflamatory drugs like Ketoprofen and Naproxen. To achieve this, it is planned to use different novel techniques such as liquisolid compacts and melt granulation.

Contributors

Author:
Nagabandi, Vijaykumar
Tadikonda, Rama Rao
Narasimha, Jayaveera

Further information

Biography Artist:
Dr. Vijaykumar Nagabandi, is currently working as Formulation Research Scientist, at Neuheit Pharma Technologies Pvt Ltd. His research is focussed on improving bioavailability of poorly soluble drugs. He authored 30 publications in peer reviewed journals and he authored one text book on "Biopharmaceutics & Pharmacokinetics
Language:
English
Number of Pages:
292
Media Type:
Softcover
Publisher:
LAP Lambert Academic Publishing

Master Data

Product Type:
Paperback book
Release date:
June 9, 2016
Package Dimensions:
0.22 x 0.15 x 0.017 m; 0.481 kg
GTIN:
09783659894350
DUIN:
H7I5RL8S5L8
$92.99
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