Synthetic & Natural Bionaphthoquinones

by Sharma, Garima
State: New
$88.99
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Sharma, Garima Synthetic & Natural Bionaphthoquinones
Sharma, Garima - Synthetic & Natural Bionaphthoquinones

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Description

This book is based on naphthoquinones and their biological evaluation for different targets (DNA topoisomerase-I, COX-2, Neuraminidase). Enzyme and cyto-toxicity assay was performed with molecular docking studies. 3, 3'-(arylmethylene) bis (2-hydroxynaphthalene-1, 4 dione) derivatives were synthesized from lawsone by two methods 1] in presence of LiCl 2] amino acid ester. DNA topoisomerase-I enzyme inhibition studies were conducted with simultaneous and preincubation conditions. Total inhibition compared to Camptothecin as positive control on both the systems of enzyme inhibition systems as well as on Leishmania donovani promastigotes. Diospyrin was isolated in a fairly large quantity from the stem bark of Diospyros montana Roxb.(family: Ebenaceae). Extraction of diospyrin from dried stem bark of Diospyros montana by petroleum ether (60-80) and chloroform in soxhlet apparatus for 2 days. The book describes about the synthetic as well as natural naphthoquinones and their biological evaluation with the help of molecular docking.

Contributors

Author:
Sharma, Garima

Further information

Biography Artist:
Prof. (Dr.) Garima Sharma, Ph.D. in Chemistry, is Professor in Chemistry and Deputy Director Research. Having rich industrial & laboratory experience of ten years, she is supervising the Research Scholars. She gives extensive hands-on training in using various Software like ChemDraw, Auto Dock, NMR, GraphPad Prism, Avogadro, Mendeley, etc.  
Language:
English
Number of Pages:
216
Media Type:
Softcover
Publisher:
LAP Lambert Academic Publishing

Master Data

Product Type:
Paperback book
Release date:
July 2, 2020
Package Dimensions:
0.22 x 0.15 x 0.012 m; 0.367 kg
GTIN:
09786202670401
DUIN:
URMFIH5U1RV
$88.99
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