Synthetic & Natural Bionaphthoquinones
by Sharma, Garima
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This book is based on naphthoquinones and their biological evaluation for different targets (DNA topoisomerase-I, COX-2, Neuraminidase). Enzyme and cyto-toxicity assay was performed with molecular docking studies. 3, 3'-(arylmethylene) bis (2-hydroxynaphthalene-1, 4 dione) derivatives were synthesized from lawsone by two methods 1] in presence of LiCl 2] amino acid ester. DNA topoisomerase-I enzyme inhibition studies were conducted with simultaneous and preincubation conditions. Total inhibition compared to Camptothecin as positive control on both the systems of enzyme inhibition systems as well as on Leishmania donovani promastigotes. Diospyrin was isolated in a fairly large quantity from the stem bark of Diospyros montana Roxb.(family: Ebenaceae). Extraction of diospyrin from dried stem bark of Diospyros montana by petroleum ether (60-80) and chloroform in soxhlet apparatus for 2 days. The book describes about the synthetic as well as natural naphthoquinones and their biological evaluation with the help of molecular docking.
Prof. (Dr.) Garima Sharma, Ph.D. in Chemistry, is Professor in Chemistry and Deputy Director Research. Having rich industrial & laboratory experience of ten years, she is supervising the Research Scholars. She gives extensive hands-on training in using various Software like ChemDraw, Auto Dock, NMR, GraphPad Prism, Avogadro, Mendeley, etc.
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LAP Lambert Academic Publishing
July 2, 2020
0.22 x 0.15 x 0.012 m; 0.367 kg