FOXA2 and MicroRNA-124 in relation with HCC sexual dimorphism in Egypt

by Mostafa, Nourhan
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Mostafa, Nourhan FOXA2 and MicroRNA-124 in relation with HCC sexual dimorphism in Egypt
Mostafa, Nourhan - FOXA2 and MicroRNA-124 in relation with HCC sexual dimorphism in Egypt

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Description

Hepatocellular carcinoma (HCC) is sexually dimorphic in mammals. Forkhead box A2 (FOXA2) binding sites' mutations exhibited impairment in binding between FOXA2, hormonal receptors and their target genes. Some miRNA genes were found to be located in cancer-associated genomic regions, indicating that they are cancer-related and could be used as prognostic and diagnostic biomarkers as well as potential molecular targets. Molecular mechanism underlying sexual dimorphism remains unclear. This study aimed to investigate FOXA2 DNA binding domain (DBD) polymorphism and miRNA-124 expression profile to correlate its differential expression to HCC in view of sexual dimorphism in Egyptian patients.

Contributors

Author:
Mostafa, Nourhan

Further information

Biography Artist:
Miss Nourhan Y. Mostafa was born in 1990 and was graduated from Biotechnology Program, Faculty of Science, Cairo University in 2011. In 2012, she worked as Research Assistant in NRC, Egypt. In 2013, she was appointed as a Demonstrator in Biotechnology Program. She received her M.Sc in Biotechnology from Faculty of Science, Cairo University in 2016.
Language:
English
Number of Pages:
156
Media Type:
Softcover
Publisher:
Scholar's Press

Master Data

Product Type:
Paperback book
Release date:
March 31, 2016
Package Dimensions:
0.22 x 0.15 x 0.009 m; 0.281 kg
GTIN:
09783659837401
DUIN:
EGEDA42FLTM
$75.79
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