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Role of TLR9 in Atherosclerosis? Therapeutic ODN in heart disease?

by Yung-Chih Chen - Sold by Dodax
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Yung-Chih Chen Role of TLR9 in Atherosclerosis? Therapeutic ODN in heart disease?
Yung-Chih Chen - Role of TLR9 in Atherosclerosis? Therapeutic ODN in heart disease?

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Delivery: between 2021-03-15 and 2021-03-17
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Description

Atherosclerosis is the underlying pathology of diseases, such as coronary artery disease, resulting in major overall mortality and morbidity. It is a chronic inflammatory disease of the arterial wall, in which the innate immune system has a pivotal contribution. Toll-like receptor-9 (TLR9) is a major intracellular innate immune receptor that has attracted major interest and is currently clinically tested as a therapeutic target of inflammatory diseases. Using apolipoprotein E-deficient mice fed with high-fat diet during periods of 8 to 20 weeks as a model of atherosclerosis, we used a genetic (TLR9 deletion) and a pharmacological approach (TLR9 agonist) to demonstrate a protective role of TLR9 in atherosclerosis. We describe the modulation of cell numbers and inflammatory phenotype of CD4+ T cells as a potential mechanism. Moreover, we have identified a novel and attractive therapeutic approach to attenuate progression of atherosclerotic disease based on the use of TLR9-activating CpG oligodeoxynucleotides.

Contributors

Author Yung-Chih Chen

Product Details

DUIN 2VVOQ8T816O

GTIN 9783659534447

Pages 56

Product type Paperback

Dimension 8.66 x 5.91  inches

$37.99
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