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Insilico Binding Studies of Phenolic Compounds With Tyrosinase

Vitiligo Is an Acquired Cutaneous Skin Disease Characterized By Declining Melanocyte Function and Depigmentation
by Upendra Bhele - Sold by Dodax EU
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Upendra Bhele Insilico Binding Studies of Phenolic Compounds With Tyrosinase
Upendra Bhele - Insilico Binding Studies of Phenolic Compounds With Tyrosinase

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Delivery: between 2021-03-08 and 2021-03-10
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Description

Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.

Contributors

Author Upendra Bhele

Product Details

DUIN 338R78U8IA8

GTIN 9783659463747

Pages 96

Product type Paperback

Dimension 8.66 x 5.91  inches

$66.30
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